The eighth edition of Design and Analysis of Experiments continues to provide extensive and in–depth information on engineering, business, and statistics–as well as informative ways to help readers design and analyze experiments for improving the quality, efficiency and performance of working systems. Furthermore, the text maintains its comprehensive coverage by including: new examples, exercises, and problems (including in the areas of biochemistry and biotechnology); new topics and problems in the area of response surface; new topics in nested and split–plot design; and the residual maximum likelihood method is now emphasized throughout the book.