Acute and Chronic Neural Stimulation via Mechano-Sensitive Ion Channels 1st ed.

Author

• Tay, Andy Kah Ping

Additional Author(s)

-

Publisher

Cham, Switzerland : Springer International Publishing, 2018

Language

English

ISBN

9783319690599

Series

Springer Theses, Recognizing Outstanding Ph.D. Research

Subject(s)

• BIOMEDICAL ENGINEERING
• NANOSCIENCE
• NANOSTRUCTURES

Notes

. .

Abstract

This book describes the tools, developed by the author, for perturbing endogenous mechano-sensitive ion channels for magneto-mechanical neuro-modulation. He explores the ways in which these tools compare against existing ones such as electricity, chemicals, optogenetics, and techniques like thermos/magneto-genetics. The author also reports on two platforms—magnetic ratcheting and magnetic microfluidics for directed evolution and high throughput culture of magnetotactic bacteria—that produce high quality magnetic nanoparticles for biomedical applications like neural stimulations. This thesis was submitted to and approved by the University of California, Los Angeles.

Introduces technology for non-invasive control of neural activities that offer deep tissue penetration and controllable dosage;
Examines the effects of biomechanical forces on cellular functions;
Explores how to improve the reproducibility and uptake of magnetic tools for non-invasive neural modulation.

Physical Dimension

Number of Page(s)

1 online resource (xvii, 119 p.)

Dimension

-

Other Desc.

ill. (in col.)

Summary / Review / Table of Content

Micro- and Nano-Technologies to Probe Brain Mechanobiology --
Acute Neural Stimulation --
Chronic Neural Stimulation --
Phenotypic Selection of Magnetospirillum magneticum (AMB-1) Over-Producers using Magnetic Ratcheting -- Magnetic Microfluidic Separation for Estimating the Magnetic Contents of Magnetotactic Bacteria --
Outlook for Magnetic Neural Stimulation Techniques. .

Exemplar(s)

#	Accession No.	Call Number	Location	Status
1.	00569/20	616.8046 Tay A	Online !	Available